IVOMEC EPRINEX Pour-On delivers highly effective internal and external parasite control in one application. Discovered and developed by scientists from Merck Research Laboratories, IVOMEC EPRINEX Pour-On contains eprinomectin, a unique avermectin. Its broad-spectrum efficacy in a weatherproof formulation, margin of safety, zero slaughter withdrawal and zero milk discard, make it a convenient product for parasite control in beef and dairy cattle, including lactating dairy cattle.
MODE OF ACTION
Eprinomectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells.
This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).
The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.
IVOMEC EPRINEX (eprinomectin) Pour-On is indicated for the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi), lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies in beef and dairy cattle of all ages, including lactating dairy cattle.
Applied at the recommended dose volume of 1 mL/10 kg (22 lb) body weight, to achieve a dose level of 500 mcg eprinomectin/kg body weight, IVOMEC EPRINEX Pour-On is indicated for the effective treatment and control of the following parasites.
Haemonchus placei (adults and L4)
Ostertagia ostertagi (including inhibited L4) (adults and L4)
Trichostrongylus axei (adults and L4)
Trichostrongylus colubriformis (adults and L4)
Trichostrongylus longispicularis (adults only)
Cooperia oncophora (adults and L4)
Cooperia punctata (adults and L4)
Cooperia surnabada (adults and L4)
Nematodirus helvetianus (adults and L4)
Oesophagostomum radiatum (adults and L4)
Bunostomum phlebotomum (adults and L4)
Strongyloides papillosus (adults only)
Trichuris spp. (adults only)
Dictyocaulus viviparus (adults and L4)
Cattle Grubs (all parasitic stages)
IVOMEC EPRINEX (eprinomectin) Pour-On for Beef and Dairy Cattle has been proved to effectively control infections and to protect cattle from re-infection with Dictyocaulus viviparus for 21 days after treatment and Haematobia irritans for 7 days after treatment.
The product is formulated only for external application to beef and dairy cattle. The dose rate is 1 mL/10 kg (22 lb) of body weight. The product should be applied topically along the backline in a narrow strip extending from the withers to the tailhead.
Squeeze-Measure-Pour System (250 mL/8.5 fl oz Bottle with 25 mL Metering Cup)
Attach the metering cup to the bottle.
Set the dose by turning the top section of the cup to align the correct body weight with the pointer on the knurled cap. When body weight is between markings, use the higher setting.
Hold the bottle upright and squeeze it to deliver a slight excess of the required dose as indicated by the calibration lines. By releasing the pressure, the dose automatically adjusts to the correct level. The off (STOP) position will close the system between dosing. Tilt the bottle to deliver the dose.
NADA 141-079, Approved by the FDA
Contains 5 mg eprinomectin/mL