VOMEC EPRINEX Pour-On delivers highly effective internal and external parasite control in one application. Discovered and developed by scientists from Merck Research Laboratories, IVOMEC EPRINEX Pour-On contains eprinomectin, a unique avermectin. Its broad-spectrum efficacy in a weatherproof formulation, margin of safety, zero slaughter withdrawal and zero milk discard, make it a convenient product for parasite control in beef and dairy cattle, including lactating dairy cattle.

MODE OF ACTION

Eprinomectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells.

This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).

The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.

INDICATIONS

IVOMEC EPRINEX (eprinomectin) Pour-On is indicated for the treatment and control of gastrointestinal roundworms (including inhibited Ostertagia ostertagi), lungworms, grubs, sucking and biting lice, chorioptic and sarcoptic mange mites, and horn flies in beef and dairy cattle of all ages, including lactating dairy cattle.

Applied at the recommended dose volume of 1 mL/10 kg (22 lb) body weight, to achieve a dose level of 500 mcg eprinomectin/kg body weight, IVOMEC EPRINEX Pour-On is indicated for the effective treatment and control of the following parasites.

Gastrointestinal Roundworms

Haemonchus placei (adults and L4)

Ostertagia ostertagi (including inhibited L4) (adults and L4)

Trichostrongylus axei (adults and L4)

Trichostrongylus colubriformis (adults and L4)

Trichostrongylus longispicularis (adults only)

Cooperia oncophora (adults and L4)

Cooperia punctata (adults and L4)

Cooperia surnabada (adults and L4)

Nematodirus helvetianus (adults and L4)

Oesophagostomum radiatum (adults and L4)

Bunostomum phlebotomum (adults and L4)

Strongyloides papillosus (adults only)

Trichuris spp. (adults only)

Lungworms

Dictyocaulus viviparus (adults and L4)

Cattle Grubs (all parasitic stages)

Hypoderma lineatum

Hypoderma bovis

Lice

Damalinia bovis

Linognathus vituli

Haematopinus eurysternus

Solenopotes capillatus

Mange Mites

Chorioptes bovis

Sarcoptes scabiei

Horn Flies

Haematobia irritans

Persistent Activity

IVOMEC EPRINEX (eprinomectin) Pour-On for Beef and Dairy Cattle has been proved to effectively control infections and to protect cattle from re-infection with Dictyocaulus viviparus for 21 days after treatment and Haematobia irritans for 7 days after treatment.