Vitamin E is a mjor antioxidant and the primary defense against lipid peroxidation. Selenium is an essential trace mineral that has been added as a synergist to complement Vitamin E. Selenium may reduce the risk of certain cancers. However, the FDA has determined that this evidence is limited and not conclusive. From the FDA's website "Some scientific evidence suggest that consumption fo antioxidant vitamins may reduce the risk of certain forms of cancer. However, the FDA has detemined that this evidence is limited and not conclusive."