SAMe (S-adenosylmethionine), a compound native to the body, is a critical component of many biochemical reactions, including those that affect brain biochemistry and joint health. Numerous studies have indicated that SAMe can help to temporarily alleviate aches and pains resulting from overexertion or stress. Therefore, SAMe is an natural product that can be part of a nutritional program for pain management. In addition, because SAMe is also necessary for the synthesis of neurotransmitters, it plays an important role in the regulation of mood. NOW SAMe is enteric-coated, which makes it very well tolerated and protects it from degradation.