Research suggests that Zyflamend may be an effective strategy to promote healthy joint function and normal cell growth, both functions which are necessary for a healthy response to inflammation. This supplement utilizes the power of Supercritical Herbal Extracts, meaning Super Purity, Super Potency, Broad Spectrum, and No Chemical Solvents. The finest herbs available are used for their precious ingredients in order to create a highly concentrated extract (as high as 250 to 1), while their potency and stability are still preserved through the use of a gentle process. New Chapter does not add synthesized additives to their extracts or isolate out single ingredients, meaning that the organic complexity and nuances of the herb are preserved, and they do not contain any chemical solvents.

The first active ingredient in Zyflamend is rosemary, which is a stimulant and a mild analgesic. It has been traditionally used to assist in the relief of muscle spasms and pain, as well as support for the nervous and circulatory systems. It has been shown to have antioxidant properties and help reduce inflammation. Rosemary also helps to relax muscles.

Turmeric is used because of curcumin, which is a powerful compound, giving turmeric its therapeutic benefits. Curcumin has anti-inflammatory and antioxidant effects. Turmeric is thought to assist in reducing inflammation by lowering the body's histamine levels, and it may also stimulate the adrenal glands, which increases the production of a hormone that reduces inflammation. It has often been used to ease inflammation and joint pain. Turmeric also carries rich stores of antioxidants, which is beneficial for general health and well-being.

Ginger is also used because it contains chemicals that help to reduce inflammation.