Emerging research demonstrates that gamma-Tocopherol, the most abundant form of Vitamin E in the diet, has very important and unique functions. Central to these functions is its capacity to detoxify reactive nitrogen species, an especially destructive form of free radical. In addition, gamma-Tocopherol acts to trap and remove free radicals from the body in a way that alpha-Tocopherol cannot. NOW Advanced Gamma E Complex provides the necessary full range of antioxidant protection because it contains a more natural balance of Tocopherols plus a full complement of Tocotrienols. NOW's advanced formula thereby provides superior support for cardiovascular health, as well as protection for the health of the prostate and the colon.
From the FDA's website: "Some scientific evidence suggests that consumption of antioxidant vitamins may reduce the risk of certain forms of cancer. However, FDA has determined that this evidence is limited and not conclusive."
Take 2 softgels one to two times daily with meals.
Serving Size: 2 Softgels Servings per Container: 60
|Ingredients||Amount per Serving||% Daily Value|
|Calories from Fat||7|
|Total Fat||0.8 g||2%|
|Trans Fat||0 g|
|Vitamin E (as Natural d-alpha Tocopherol)||400 IU|
|Natural Mixed Tocopherols||400 mg|
|Tocomin® Mixed Palm Tocotrienol Complex||10 mg|
|* Percent Daily Values are based on 2,000 calorie diet.|
|† Daily Value not established|
Other Ingredients: Softgel Capsule (gelatin, glycerin, water, carob), Rice Bran Oil and Red Palm Fruit Oil. Contains soy derivatives. Contains only 100% Natural Vitamin E.
Contains no: sugar, salt, starch, yeast, wheat, gluten, corn, milk, egg, shellfish or preservatives.
Caution: Do Not Eat Freshness Packet. Keep in Bottle.
Each serving may typically provide the following naturally occurring Mixed Tocopherols and Mixed Tocotrienols: gamma-Tocopherol 300 mg, delta-Tocopherol 80 mg, beta-Tocopherol 5 mg, gamma-Tocotrienol 5.5 mg, alpha-Tocotrienol 3.0 mg, delta-Tocotrienol 0.9 mg, beta-Tocotrienol 0.3 mg.
Tocomin® is a registered trademark of Carotech Inc.
Store in a cool, dry place.
What's the difference between Alpha and Gamma and Tocopherol?
In order to answer the question correctly we need to review what Vitamin E is. Vitamin E is actually a family of essential fat-soluble nutrients that act as powerful antioxidants. In nature, there are eight substances that comprise vitamin E: alpha-, beta-, gamma- and delta- tocopherols; and alpha-, beta-, gamma- and delta- tocotrienols. The four different isomers (alpha, beta, gamma and delta) from both the tocopherol and tocotrienol groups all have different biological activities and potential therapeutic benefits.
Research shows that d-alpha-tocopherol has the highest bioavailability and is the standard against which all the others must be compared. This is the only natural form of Vitamin E that is measured in International Units (IU). Human blood and tissue contains much more alpha-tocopherol than gamma-tocopherol even though gamma-tocopherol is the predominant form of vitamin E in our diet. That is because the body has a special preferred transport mechanism for alpha-tocopherol.
Is there any research on Gamma-tocopherol’s health benefits?
Research suggests its configuration enables it to better trap and quench reactive nitrogen oxide species (RNOS) such as peroxynitrate and nitrogen dioxide. These dangerous free radical compounds are formed in excess during an inflammatory episode. The structure of alpha-tocopherol does not allow it to bind these nitrogen compounds. Gamma-tocopherol’s ability to provide protection against these damaging RNOS makes it an extremely important weapon to protect cardiovascular health, brain tissue and normal cellular functions.
Gamma-tocopherol has been researched at the University of California, Berkeley and Children’s Hospital Oakland Institute and shown to have a COX-2 (cyclo-oxygenase 2) inhibitory effect on human epithelial cells, as well as the ability to inhibit PGE2 ( prostaglandin E-2) synthesis.
COX-2 is the bad guy enzyme that is found mainly in inflammatory conditions and generates the production of pro-inflammatory prostaglandins involved in cellular damage. By inhibiting COX-2 activity, gamma-tocopherol plays an important role in protecting the body.
What are tocotrienols?
Tocotrienols are the cousins of tocopherols that exhibit vitamin E antioxidant activity. Their chemical structure is different in that they have an unsaturated side-chain rather than the saturated side-chain of tocopherols. The unique molecular structure of tocotrienols allows them to be more efficiently and uniformly distributed into cell membranes and tissues that are high in unsaturated fatty acids, such as the brain and liver.
Plant oils are the best sources of both tocotrienols and tocopherols. Virgin palm oil is the best single source of tocotrienols, providing the four isomers, alpha-, beta-, gamma- and delta. Although some studies performed on animals and humans have shown that certain tocotrienols have an ability to inhibit oxidation of LDL cholesterol, help regulate cholesterol production, and inhibit certain abnormal cell line growth, more clinical research is needed to validate the findings and translate them into a specific dose response.