Vetericyn Wound and Infection spray gets our number one vote! Not only will it help clear up the hot spots, but is also extremely useful in helping treat a number of skin issues, including: hot spots, mange, rain rot, rashes, post-surgical sites, burns, cinch fungus, ring worm, skin infections, scratches, eye infection, respiratory tract associated infections, skin ulcers, E.Coli, salmonella, strep, and staph! This is a must have to keep on hand for any pet owner!